Clinical Development of MR Spectroscopy and Imaging in Brain Cancers

Inclusion Criteria: (120 Brain Tumor Patients) * All races and ethnicities * Must meet at least one of the 3 following criteria regarding diagnosis: * Histological diagnosis of a brain tumor * Pre-operative MR imaging suggestive of a brain tumor * Radiographic diagnosis of brain tumor in an inoperable location (e.g. brainstem) * Pretreatment evaluations required for eligibility include a medical history, physical examination, and neurological exam within 30 days prior to study entry. * Patient must be able to provide study-specific consent prior to study entry and Health Insurance Portability and Accountability Act of 1996 (HIPAA) authorization. * Karnofsky performance status \>70% * Life expectancy greater than 3 months. (50 Non-Tumor Neurological Disorders) * All races and ethnicities * Patients with clinically-proven multiple sclerosis, temporal lobe epilepsy, stroke, or encephalitis. (5 Health Volunteers) * 18-40 years of age * All races and ethnicities * Excellent general health Exclusion Criteria: * Under age 18 * Cardiac pacemaker * Intracranial clips, metal implants, or external clips within 50 cm from the head * Metal in eye * Pregnancy * Claustrophobia * Obesity or any other factors that provide difficulty with supine pose in the magnet * Patients who are unable to provide informed consent * Patients who are pregnant or nursing * Patients with severe kidney dysfunction or uncontrolled cardiac dysfunction * Patients who are claustrophobic or have other contraindication to MRI, such as implanted pacemaker device, vascular clips, surgical clips, prosthetic valves, pace¬makers, otologic implants * Patients with uncontrolled psychiatric manifestations of their brain tumor * Patients for 7 Tesla scans can have no metal in the body