Phenolic-rich Oats and Artery Improvement

University of Reading18 enrolled

Overview

In this proposed human trial, the investigators aim to establish whether consumption of one portion of phenolic acid-rich oats leads to acute improvements (i.e. 1-24h post-intake) in markers of cardiovascular disease risk relative to an energy matched control intervention in healthy men with high-normal to mildly elevated blood pressure.

A diet rich in whole grain is inversely associated with cardiovascular disease risk. Whole grains contain a wide range dietary components including potentially vasoactive phenolic acids.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

OatOTHER

The study oat intervention products will consist of 67.7g oatflake and 22.5g oatbran concentrate.

ControlOTHER

60g cream of rice

Eligibility

Sex: MALEMin age: 25 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Above average blood pressure (i.e. systolic 120-159 mmHg and diastolic 75-99 mmHg) Exclusion Criteria: * Abnormal biochemical, haematological results as assessed at health screening * Hypertension (i.e. systolic/diastolic blood pressure ≥160/100 mm Hg) BMI \>35 * Current smoker or ex-smoker ceasing \<3 months ago * Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer * Prescribed or taking lipid lowering, antihypertensive, vasoactive (e.g. Viagra), anti-inflammatory, antibiotic or antidepressant medication * Allergies to whole grains * Parallel participation in another research project * Having flu vaccination or antibiotics within 3 months of trial start * On a weight reduction regime or taking food supplements within 3 months of trial start * Performing high level of physical activity (i.e. \>3 x 20 min aerobic exercise/week) * Consumption of ≥21 units of alcohol/week * Small veins not allowing cannulation

Locations (2)

Hugh Sinclair Unit of Human Nutrition

Reading, Berkshire, United Kingdom

Hugh Sinclair Unit of Human Nutrition

Reading, United Kingdom

Outcomes

Primary Outcomes

Flow Mediated Dilatation

Technique to assess the flexibility of the endothelium in larger peripheral blood vessels

Time frame: 1 hour, 6 hours and 24 hours

Secondary Outcomes

Laser Doppler Iontophoresis

Acute postprandial timecourse from Baseline to 2 hours, 24hours, AUC - area under the blood flow and time curve Ach-iAUC-endothelium dependent incremental area under the curve SNP-iAUC-endothelium independent incremental area under the curve Ach-AUC- endothelium dependent area under the curve

Time frame: Baseline(BL), 2hours and 24hours

Phenolic Acids Metabolites - Ferulic Acid

Concentration of phenolic acid metabolites in plasma and urine as Assessed by liquid chromatography/mass spectrometry magnitude of increase from Baseline to 24h

Time frame: Baseline, 1hour, 2 hours and 24hours

Plasma Nitric Oxide Analysis

Concentration of nitric oxide in nmol

Time frame: Acute postprandial timecourse from Baseline, 1hour to 24hours.

NADPH Oxidase Activity in Neutrophil Blood Cells

NADPH oxidase activity will be calculated as the difference between values obtained in PMA The fluorescence intensity was measured by C6 Flow Cytometer

Time frame: Baseline, 2 hours and 24 hours

Plasma Glucose

Glucose concentration in mmol/L

Time frame: Acute postprandial timecourse from Baseline, 1hour to 24hours.

Plasma Insulin

Insulin concentration in pmol/L

Data from ClinicalTrials.gov

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