This study will evaluate the effect, safety, and tolerability of ceftazidime-avibactam (CAZ-AVI) plus vancomycin or linezolid compared to standard of care plus vancomycin or linezolid as empiric therapy in febrile neutropenic adults with cancer
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
2
Ceftazidime-Avibactam (2 g ceftazidime and 0.5 g avibactam)
15 mg/kg
600 mg
MD Anderson Cancer Center
Houston, Texas, United States
Percentage of Patients With Favorable Clinical Response at End of Inpatient Intravenous Therapy (EOIV)
Favorable clinical response is defined as resolution of all acute signs and symptoms of the primary infection or improvement to such an extent that no additional antibacterial therapy is required as assessed by the investigator. Due to study termination and limited enrollment, outcome measures were not analyzed.
Time frame: Up to Day 14
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2 g
1 g
4.5 g