MIRODERM™ for Complex Wounds in an Inpatient Setting (MIRODERM CLOSure)

Inclusion Criteria: * Be at least 18 years old * Have a complex study wound which will require an autograft or delayed primary closure procedure and which may or may not include tunneling and/or undermining * Have a study wound with a total post-debridement surface area ≥50cm2 and ≤250cm2 with no dimension \>25cm, and a minimum depth of ≥0.5cm * Have a study wound which is expected to take at least 4 weeks to reach autograft or delayed primary closure using standard care and NPWT * Have a study wound that will be treated with NPWT regardless of study participation * Be in an inpatient setting * Be able and willing to sign the consent form and comply with all study visits and procedures Exclusion Criteria: * Be pregnant or be planning to become pregnant during the study * Be contraindicated for NPWT (necrotic tissue with eschar present, untreated osteomyelitis, non-enteric and unexplored fistulas, malignancy in the wound, exposed vasculature, exposed nerves, exposed anastomotic site, exposed organs) * Be immunocompromised or at risk of immunosuppression (e.g. be HIV positive, be experiencing organ rejection, be a recent, current, or anticipated chemotherapy recipient) as determined by the Investigator * Be taking a Tumor Necrosis Factor (TNF) blocker * Be participating in another research study * Have a sensitivity to porcine material * Have a life expectancy of less than 1 year * Have a study wound which is a third degree burn wound * Have a study wound that is infected * Have a study wound that is a pressure ulcer/wound * Have a study wound with sinus tract(s) leading to other open area(s) * Have a wound that is being treated or expected to be treated with either HBOT or topical wound oxygen therapy * Have a study wound which has been treated with a cellular and/or tissue-based product within last 30 days