Histones and Free-plasma DNA After Cardiac Arrest

Inclusion Criteria: * Out of hospital cardiac arrest of presumed cardiac cause * Return of spontaneous circulation (ROSC) * Glasgow Coma Score \< 8 * Age \> 18 years and \< 80 years Exclusion Criteria: * \>60 minutes from the circulatory collapse to ROSC * Time interval \> 4 hours from cardiac arrest to initiation of targeted temperature management * Terminal illness * Coagulation disorder * Unwitnessed asystolia * Cerebral performance category 3-4 before the cardiac arrest * Severe persistent cardiogenic shock * Pregnancy * Persistent cardiogenic shock (systolic blood pressure \< 80 despite inotropic treatment) * New apoplexy or intracerebral hemorrhage * Lack of consent from the relatives * Lack of consent from the general practitioner * Lack of consent from the patient if he/she wakes up and is relevant