Cross-over Study to Evaluate the Safety and Efficacy of Night Closed-loop Control Using the MD-Logic Automated Insulin Delivery System Compared to Sensor Augmented Pump Therapy in Poorly Controlled Patients With Type 1 Diabetes

Inclusion Criteria: * Subject with type 1 diabetes \>1year since diagnosis * Insulin infusion pump (CSII) therapy for at least 3 months * Patients able to use sensor after training based on researcher's estimation * Age between 10 and 18 years (both included) * HbA1c at inclusion between 7.5 and 11.0 % (both included) * Patients willing to follow study instructions * Patients live with at least one other adult person * Body Mass Index Standard Deviation Score - below the 95th percentile for age * Patients with caregivers who are capable of operating a computer based system Exclusion Criteria: * Concomitant diseases that influence metabolic control (e.g. anemia, significantly impaired hepatic function, renal failure, history of adrenal insufficiency) or other medical condition, which in the Investigator's opinion, may compromise patient safety Participation in any other interventional study * Known or suspected allergy to trial products such as adhesives, tapes, needles. An allergy to contrast medium, use of other active medical devices and planned imaging * Any significant diseases or conditions including psychiatric disorders and substance abuse that, in the opinion of the investigator, is likely to affect the subject's ability to complete the study, or compromise patient safety * Diabetic ketoacidosis in the past 1 month * Severe hypoglycemia six month prior to enrollment * Current use of the following medications: medications that are used to lower blood glucose , Beta blockers, glucocorticoids and other medications, which in the judgment of the investigator would be a contraindication to participation in the study * Subject is participating in another drug or device study that could affect glucose measurements or glucose management * Female subject who is pregnant or breast-feeding or is planning to become pregnant within the planned study duration * Not sufficient vision or hearing to recognize pump/sensor alarms or to perform Blood Glucose-self measurements 4-times daily. * Relevant severe organ disorders (diabetic nephropathy, diabetic retinopathy, diabetic foot syndrome) or any secondary disease or complication of diabetes mellitus -Subject has unstable or rapidly progressive renal disease or is receiving dialysis- * Subject has active proliferating retinopathy * Active gastroparesis * Patient suffers from an eating disorder