Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?

Adiyaman University Research Hospital198 enrolled

Overview

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. The diagnosis of acute liver dysfunction (ALD) can usually be made by initial symptoms, physical examination, and biochemical tests, including liver function tests (LFTs) with high sensitivity and specificity. LFTs include albumin, bilirubin, coagulation factors (Activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR)), and liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), and y-glutamyl transpeptidase (GGT), which are marker of hepatic damage. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of LFTs for patients with SOD in the ED, and a cost analysis of LFTs.

Study Type

OBSERVATIONAL

Enrollment

198

Conditions

Dizziness

Interventions

LFTsOTHER

A single 5-ml peripheral venous blood sample was collected from each participant. Serum ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, and albumin level, Platelet count, INR and aPTT were analyzed.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1\. Adult patients who were experiencing sudden onset dizziness of unknown etiology for the first time were included in the study Exclusion Criteria: 1. Patients with a history of chronic diseases such as any liver disease,diabetes mellitus, hypertension,congestive heart failure, hepatitis B or C infection 2. Patients with any central dizziness attacks 3. Patients with hemodynamically unstable and emesis; 4. Patients receiving drugs that could affect liver function tests, such as, acetaminophen, antibiotics, oral contraceptives, antihypertensive drugs (e.g., angiotensinconverting enzyme inhibitors), or hormones (e.g.,estrogen) 5. Patients who was experienced dizziness with systemic diseases 6. Patients with any neurological disorders 7. Patient who do not want to participate in the study

Locations (1)

Adiyaman University Research Hospital

Adıyaman, Central, Turkey (Türkiye)

Outcomes

Primary Outcomes

LFTs serum levels by biochemical method ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and Platelet count (PC)

The serum levels of LFTs will obtained by the laboratory analysis of blood samples of each participant.

Time frame: 5 months

Secondary Outcomes

The cost calculation for the LFTs

The cost for the LFTs will be calculated with financial data in invoices which will obtained from the hospital invoicing service.

Time frame: 5 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.