A multi-center, randomized, single blind, positive controlled trials that assess the effectiveness, safety and cost-effectiveness analysis in patients with mild to moderate psoriasis vulgaris and compare Compound Clobetasol Propionate Ointment to Calcipotriol Betamethasone Ointment. Objectives of Study: 1. Compare Compound Clobetasol Propionate Ointment to Calcipotriol Betamethasone Ointment in the treatment of mild to moderate psoriasis vulgaris in effectiveness and safety; 2. Compare the cost-effectiveness analysis of two treatment programs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
240
The improvement of psoriasis area and severity index scores(PASI scores)
The improvement of psoriasis area and severity index scores(PASI scores) are a system that assesses the damage of psoriasis severity and treatment response . The system is used to classify and evaluate according to the severity of lesions, areas of skin lesion and body surface area ratio of various body parts.
Time frame: At baseline, 2 weeks and 4 weeks after baseline.
The overall evaluation of the researchers (Physician Global Assessment,PGA)
On every visiting viewpoint , researchers give a mark of the infiltration / hypertrophy (I), erythema (E) and scales (s) according to the level.PGA scores are acquired by the average of above three kinds of scores.
Time frame: At baseline, 2 weeks and 4 weeks after baseline.
The Symptom score reduce index (SSRI)
1)According to the improvement of psoriasis area and severity index scores(PASI scores) before and after treatments, the symptom score reduce index (SSRI) was calculated. 2)The symptom score reduce index (SSRI) = (the PASI scores before treatment - the PASI scores after treatment) / the PASI scores before treatment x 100%
Time frame: 4 weeks after baseline.
Efficiency of treatment
1)Healing patients : SSRI ≥ 90%, Marked effectiveness patients : 60% \< SSRI \< 90%, Improvement patients : 20% \< SSRI \< 60%, ineffectiveness patients :SSRI \< 20%. 2)Efficiency of treatment = (The number of healing patients + The number of markedly effective patients + The number of improved patients ) / total number of patients in this group x 100%
Time frame: 4 weeks after baseline.
Healing rate
1)Healing patients : SSRI ≥ 90%, Marked effectiveness patients : 60% \< SSRI \< 90%, Improvement patients : 20% \< SSRI \< 60%, ineffectiveness patients :SSRI \< 20%. 2)Healing rate = The number of healing patients / total number of patients in this group x 100%
Time frame: 4 weeks after treatment
Markedly effective rate
1)Healing patients : SSRI ≥ 90%, Marked effectiveness patients : 60% \< SSRI \< 90%, Improvement patients : 20% \< SSRI \< 60%, ineffectiveness patients :SSRI \< 20%. 2)Markedly effective rate = The number of markedly effective patients / total number of patients in this group x 100%
Time frame: 4 weeks after treatment
Response rate of PASI (PASI 75) after the treatment of 4 weeks
Response rate of PASI (PASI 75) after the treatment of 4 weeks = The number of patients whose SSRI are more than 75% / total number of patients x 100%
Time frame: 4 weeks after treatment
Response rate of PGA ( basic fading rate of PGA) after the treatment of 4 weeks
Response rate of PGA ( basic fading rate of PGA) after the treatment of 4 weeks:patients with 1 score of PGA for the last time/ total number of patients in this group x 100%
Time frame: 4 weeks after treatment
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