The objective of the study was to estimate the efficacy of telmisartan and amlodipine combination on the restoration of left atrial mechanical function after atrial fibrillation catheter ablation.
64 candidates to atrial fibrillation ablation were included in the study. Patients were randomly assigned to telmisartan/amlodipine combination in dose 80/5 mg (group I, n=34) or placebo (group II, n=30) taking daily for up to one week. Echocardiography was performed before the procedure, immediately after it, and after a week of therapy. The six-minute walk test and SF-36 questionnaire results were evaluated a day before the procedure and after a week of the therapy. The left ventricular end-diastolic pressure was invasively measured after transseptal puncture and before left atrial sheath removal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
64
Sugar pill manufactured to mimic telmisartan 80 mg and amlodipine 5 mg tablet
Passive Emptying of Left Atrium
Velocity time integral of transmitral flow during left ventricle early filling phase (VTI E, cm).
Time frame: 7 days
Active Emptying of Left Atrium
Velocity time integral of transmitral flow during atrial contraction (VTI A, cm).
Time frame: 7 days
Left Atrial Reservoir Function
Velocity time integral of transmitral flow (VTITMF, cm) during the whole diastole.
Time frame: 7 days
Diastolic Function
E/A ratio of transmitral flow
Time frame: 7 days
Isovolumic Relaxation
Left ventricular isovolumic relaxation time (IVRT, ms).
Time frame: 7 days
Pulmonary Vein Flow Emptying
S/D ratio of right superior pulmonary vein flow
Time frame: 7 days
Retrograde Flow in Pulmonary Veins
Velocity time integral of right superior pulmonary vein flow during left atrial systole (VTI Ar, cm)
Time frame: 7 days
Left Atrial Contractility
Left atrial active emptying fraction (LAAEF, %)
Time frame: 7 days
Left Atrial Dimensions
Left atrial antero-posterior diameter (LAD, cm)
Time frame: 7 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Left Atrial Pressure Load
Mean left atrial pressure (MLAP, mm Hg).
Time frame: 7 days
Pulmonary Circulation Pressure Load
Right ventricular systolic pressure (RVSP, mm Hg).
Time frame: 7 days
Quality of Life
The average of eight scores of 36-Item Short Form Health Survey (SF-36). In every case all of eight scores (which ranges from 0 to 100) was summarized, then the sum was divided by 8. Thus the outcome also ranges from 0 (worse outcome) to 100 (better outcome).
Time frame: 7 days
Exercise Tolerance
six-minute walk distance in meters
Time frame: 7 days