Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. Raspberries are rich in phenolic and polyphenolic compounds, in particular procyanidins, ellagitannins and anthocyanins, but also phenolic acids. At present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk have shown promising results. However, to date, very few human studies have specifically investigated the effects of raspberry (poly)phenols on cardiovascular function in healthy subjects. Moreover, ellagitannin-derived metabolites are believed to persist for a long period of time in the blood and urine. Therefore, the investigators will investigate the presence of plasma and urinary raspberry-derived metabolites 24h post-consumption. To the investigators knowledge, the effects of red raspberry consumption on vascular function in humans have not been investigated before. This information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of raspberries,. Therefore, this study aims to investigate the potential role of red raspberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
10
1x daily intake of 600 mL red raspberry beverage
1x daily intake of 600 mL red raspberry beverage
1x daily intake of 600 mL raspberry deprived supplement
Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf
Düsseldorf, Germany
Change from baseline to 2 hour and 24 hour in Endothelial function
measured by flow mediated dilation (FMD) on baseline at 2 and 24 hour postconsumption
Time frame: Baseline, 2 hour and 24 hour
Change from baseline to 2 hour and 24 hour in Pulse wave velocity
measured by sphygmomanometer SphygmoCor on baseline at 2 and 24 hours postconsumption
Time frame: Baseline, 2 hour and 24 hour
Change from baseline to 2 hour and 24 hour in Central blood pressure
measured by sphygmomanometer SphygmoCor on baseline at 2 and 24 hours postconsumption
Time frame: Baseline, 2 hour and 24 hour
Peripheral blood pressure
measured by automatic sphygmomanometer on baseline at 2 and 24 hours postconsumption
Time frame: Baseline, 2 h and 24 h
Change from baseline to 2 hour and 24 hour in Heart rate
measured by SphygmoCor on baseline at 2 and 24 hours postconsumption
Time frame: Baseline, 2 hour and 24 hour
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