The purpose of this study is to investigate the safety, effective dosage and treatment of Magnesium Isolycyrrhizinate Injection to cure the acute drug-induced liver injury compared with the Tiopronin Injection.
The pharmacology research shows that Magnesium Isoglycyrrhizinate could significantly decrease the elevation of ALT and AST coursed by carbon tetrachloride, D-galactosamine and Thioacetamide. It could also significantly reduce the injury on the liver coursed by D-galacosamine and immunologic factors. Magnesium Isoglycyrrhizinate with strong anti-inflammatory effect could protect the liver cell and improve the liver function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
174
Magnesium Isoglycyrrhizinate Injection 100mg OD
Magnesium Isoglycyrrhizinate Injection 200mg OD for 4 weeks
Tiopronin Injection 200mg OD
Beijing Chest Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Nanjing Pulmonary Hospital
Nanjing, Jiangsu, China
85 Hospital of People's Liberation Army
Shanghai, Shanghai Municipality, China
Renji Hospital Shanghai Jiaotong University School of Medicine
Rate of ALT normalization at week 4 of treatment
Time frame: 4 weeks
rates of ALT normalization at weeks 1, 2, and 3 of treatment
Time frame: 3 weeks
change of ALT at weeks 1, 2, 3 and 4 of treatment;
Time frame: 4 weeks
change of AST at weeks 1, 2, 3 and 4 of treatment.
Time frame: 4 weeks
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Shanghai, Shanghai Municipality, China
Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, China
Shanghai Sixth People's Hospital
Shanghai, Shanghai Municipality, China
Integrated Chinese and Western Medicine Hospital of Zhejiang Province
Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China