The aims of the current study is to explore if different exercise training protocols affect fatigue post-exercise, and if sarcoidosis-related fatigue and maximal and sub-maximal cardiopulmonary exercise test (CPET) variables change after a 4-weeks exercise training period.
This project aims to provide data on post-exercise fatigue after single exercise sessions with endurance training and muscle strength training, each with two different intensities. For endurance training; post-exercise fatigue will be assessed after one session of high intensity interval training, and one session with longer duration of moderate intensity. For muscle strength training, fatigue will be measured after one session with high loads/few repetitions and one session with low loads/many repetitions. In addition, changes in sub-maximal and maximal metabolic and ventilatory responses to a maximal cardiopulmonary exercise test on a treadmill (CPET) and association to sarcoidosis-related fatigue before and after a 4-weeks exercise training period will be studied.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
40
Two different muscle strength training protocols will be compared; one exercise session with high load/low repetitions (4 sets x 5RM) versus one exercise session with low load/high repetitions (2 sets x 25RM). Both session will be conducted at four different exercises; seated leg press, chest press, cable lat pull down and seated rowing.
Two different endurance exercise training protocols will be compared; one exercise sessions is interval training with high intensity (85-95% of HRmax) versus one of moderate intensity (70-75% of HRmax) with longer duration.
LHL-klinikkene Glittre
Hakadal, Norway
Change in fatigue
Changes of fatigue will be assessed assessed by Visual Analogue Scale (VAS), where the grade of fatigue is assessed between 0 (no fatigue) and 10 (maximal fatigue).
Time frame: Fatigue measured immediately before and acute after exercise sessions, (within 1 min.), and addition 24 hours post-exercise.
Change in blood lactate
Blood lactate will be assessed by capillary puncture in a finger tip.
Time frame: Blood lactate are measured before and acute after exercise sessions (within 2 min.), and in addition 24 hours post-exercise.
Change in sarcoidosis related fatigue
Assessed by the Fatigue Assessment Scale (FAS)
Time frame: Measured first day and last day of a 4-week exercise based pulmonary rehabilitation
Change in metabolic and ventilatory variables from CPET
Ratio ventilation/carbon dioxide output (VE/VCO2)
Time frame: Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation
Change in metabolic and ventilatory variables from CPET
Ventilatory (anaerobic) threshold (VT, %)
Time frame: Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation
Change in maximal oxygen uptake
Maximal oxygen uptake (VO2, mL/min)
Time frame: Measured during a CPET first day and last day of a 4-week exercise based pulmonary rehabilitation
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