The purpose of this study is to to compare lung function data generated by applying High Fidelity Functional Lung Imaging (HFFLI) software to 4D CT, cone beam CT, and fluoroscopic images of the lungs breathing to determine whether different modalities of imaging provide similar data on lung movement and function. HFFLI may detect changes in lung function in patients undergoing External Beam Radiotherapy for cancer.
This study is designed to test a novel technology to examine early changes in the lung in hopes of identifying patients who may be at risk for radiation pneumonitis. Eligible subjects will undergo standard of care treatment with the use of the Varian TrueBeam system for radiation therapy of a cancer lesion in the chest. The imaging data acquired as part of usual standard of care for these patients is a pre-treatment 4D planning CT scan, and a daily cone beam CT at each radiation treatment visit. We will also obtain a series of images consisting of five six-second cinefluorographs (real time fluoroscopic movies, for a total each time of 30 seconds of fluoroscopy) of the lungs while the subject is breathing, each at precisely measured angles to the subject, on 4 different occasions. This study will compare lung function data generated by applying High Fidelity Functional Lung Imaging (HFFLI) software to 4D CT, cone beam CT, and fluoroscopic images of the lungs breathing to determine the degree of correlation between data generated from different imaging modalities. The study is open to adults over the age of 18, at any stage of cancer.
Study Type
OBSERVATIONAL
Enrollment
60
The initial 4DCT imaging obtained as part of a subject's planning CT for their standard radiation treatment.
Daily cone beam CT imaging at each radiation treatment visit, as part of standard care
A series of images consisting of five six-second cinefluorographs (real time fluoroscopic movies, for a total each time of 30 seconds of fluoroscopy) of the lungs while the subject is breathing, each at precisely measured angles to the subject, on 4 different occasions.
Pulmonary Function Testing (PFT) gives global functional data for the lungs as a whole, but is relatively insensitive to early pathological changes. It involves taking very deep breaths and exhaling as forcefully as possible. Research PFTs will be conducted at 4 and 12-months post radiation therapy
Cedars-Sinai Medical Center
Los Angeles, California, United States
A Pearson correlation of >0.579 between peak expiratory flow as measured by HFFLI analysis of cinefluorograph compared with 4D planning CT
Time frame: Baseline
A Pearson correlation of >0.579 between peak inspiratory flow as measured by HFFLI analysis of cinefluorograph compared with 4D planning CT
Time frame: Baseline
A Pearson correlation of >0.579 between ventilation/local time constant as measured by HFFLI analysis of cinefluorograph compared with 4D planning CT
Time frame: Baseline
A Pearson correlation of >0.579 between expiratory time constant as measured by HFFLI analysis of cinefluorograph compared with 4D planning CT
Time frame: Baseline
A Pearson correlation of >0.579 between inspiratory time constant as measured by HFFLI analysis of cinefluorograph compared with 4D planning CT
Time frame: Baseline
A Pearson correlation of >0.579 between tissue shear as measured by HFFLI analysis of cinefluorograph compared with 4D planning CT
Time frame: Baseline
A Pearson correlation of >0.579 between peak expiratory flow as measured by HFFLI analysis of cinefluorograph compared with cone beam CT
As part of standard care, patients will have a cone beam CT on each day they receive radiation treatment. Treatment period varies.
Time frame: During radiation therapy
A Pearson correlation of >0.579 between peak inspiratory flow as measured by HFFLI analysis of cinefluorograph compared with cone beam CT
As part of standard care, patients will have a cone beam CT on each day they receive radiation treatment. Treatment period varies.
Time frame: During radiation therapy
A Pearson correlation of >0.579 between ventilation/local time constant as measured by HFFLI analysis of cinefluorograph compared with cone beam CT
As part of standard care, patients will have a cone beam CT on each day they receive radiation treatment. Treatment period varies.
Time frame: During radiation therapy
A Pearson correlation of >0.579 between expiratory time constant as measured by HFFLI analysis of cinefluorograph compared with cone beam CT
As part of standard care, patients will have a cone beam CT on each day they receive radiation treatment. Treatment period varies.
Time frame: During radiation therapy
A Pearson correlation of >0.579 between inspiratory time constant as measured by HFFLI analysis of cinefluorograph compared with cone beam CT
As part of standard care, patients will have a cone beam CT on each day they receive radiation treatment. Treatment period varies.
Time frame: During radiation therapy
A Pearson correlation of >0.579 between tissue shear as measured by HFFLI analysis of cinefluorograph compared with cone beam CT
As part of standard care, patients will have a cone beam CT on each day they receive radiation treatment. Treatment period varies.
Time frame: During radiation therapy
Forced expiratory volume 1 (FEV1)
Time frame: At 12 months post radiation
FEV1/Forced vital capacity
Time frame: At 12 months post radiation
Total lung capacity
Time frame: At 12 months post radiation
Diffusing capacity for carbon monoxide
Time frame: At 12 months post radiation
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