Decreases in Diffusing Lung Capacity for Carbon Monoxide (DLCO) in Occupational Divers and Their Impact on Decompression Sickness Risks

University Hospital, Brest16 enrolled

Overview

Diving disorders and particularly Decompression sickness (DCS) represent a major concern in recreational and occupational pressure-related activities. As a result of decompression from higher to lower ambient pressure bubbles which are formed in vascular flow and in tissues take part in embolism then resulting in DCS. Individual factors such as vascular or respiratory defects are now considered to increase the risk of this dysbarism disease.

2 groups of occupational divers will be separated after a fitness medical examination by regarding DLCO decrease or not. The divers will be evaluated before and 30, 60, 180 minutes after a 20 meters air dive. Venous bubbles will be detected by precordial Doppler 30 minutes after the dive. In association with this Doppler, Flow Mediated Dilation, blood samples analysing inflammatory and thrombotic factors and other biomarkers will be explored before and after the dive in order to know how vascular and respiratory tracts in this environment react.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Decompression Sickness

Interventions

20 meters air diveOTHER

A dive in the depth of 20 m during 40 minutes. The divers will be evaluated before and 30, 60, 180 minutes after a 20 meters air dive. Venous bubbles will be detected by precordial Doppler 30 minutes after the dive. In association with this Doppler, Flow Mediated Dilation, blood samples analysing inflammatory and thrombotic factors and other biomarkers will be explored before and after the dive in order to know how vascular and respiratory tracts in this environment react.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Be professional and voluntary diver * Man or woman aged 18 years or older * Diffusing Lung Capacity for Carbon Monoxide measured beforehand in the study * No medical contraindication for hyperbaric * No hyperbaric constraint in 3 days before the dive * No prior Decompression sickness * Not to follow medicinal treatment modifying the vascular endothelial and/or the coagulation and/or the respiratory function * Patient affiliated to social security * Informed and signed Exclusion Criteria: * Concomitant pathology identified by the Investigator, justifying a contraindication for hyperbaric * Pregnant and nursing mothers * Patient who refuse to sign consent form

Locations (1)

Brest, University Hospital

Brest, France

Outcomes

Primary Outcomes

Venous bubbles will be detected by precordial Doppler

Time frame: 30 minutes after the dive

Secondary Outcomes

Vascular abnormality

Assessement of microvascular reactivity by brachial artery flow mediated dilation

Time frame: 60 minutes after the dive

Coagulation activation

Assessment of blood coagulation factor after the dive

Time frame: 60 minutes after the dive

Inflammatory activation

Assessment of inflammatory factor after the dive

Time frame: 60 minutes after the dive

Data from ClinicalTrials.gov

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