Traditionally, the use of GnRH-a suppression was considered essential for adequate endometrial hormonal modulation in cryopreserved-thawed embryo transfer cycles. Several studies, however, have questioned its necessity for controlled endometrial preparation. Using a high dose of estradiol from day 1 of the cycle will suppress the gonadotroph, preventing folliculogenesis and excessive secretion of LH, allowing adequate endometrial preparation without GnRH-a.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
310
The transfer of cryopreserved-thawed embryos inside the uterus aiming to achieve pregnancy
Serum estradiol and serum progesterone levels in blood on the day of start of progesterone supplementation
GnRH agonist given on day 21 of the cycle preceding the embryo transfer
IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini)
Cairo, Egypt
Kamal Shaeer center of infertility
Giza, Egypt
Nile IVF center
Giza, Egypt
Clinical pregnancy rate
the detection of intrauterine gestational sac with positive pulsations
Time frame: 5 weeks after embryo transfer]
Live birth rate
Pregnancy ending with a live birth
Time frame: 9 months
Estradiol and Progesterone levels on day of start of progesterone supplementation
The serum levels of estradiol and progesterone before embryo transfer
Time frame: 12 to 20 days
Endometrial thickness on day of start of progesterone supplementation
The endometrial thickness on the day of starting progesterone supplementation to transfer the embryos
Time frame: 12 to 20 days
Number of days needed for adequate (> 8mm) endometrial thickness
Number of days on external hormones to prepare endometrium
Time frame: 12 to 20 days
Cycle cancellation: not related to thawing, thin endometrium, high P. OR related to embryos not surviving thawing.
Cycle cancellation: not related to thawing, thin endometrium, high Progesterone. OR related to embryos not surviving thawing.
Time frame: 12 to 20 days
Chemical pregnancy rate
positive serum Beta HCG 14 days after embryo transfer
Time frame: 14 days after embryo transfer
Implantation rate.
the ratio between the number of embryos transferred and the number of sacs
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Estradiol started on day1 of the cycle for endometrial prepartaion
progesterone as luteal phase support start after endometrium is well prepared
Time frame: 5 weeks after embryo transfer
Early miscarriage rate
Pregnancy loss in the first 12 weeks gestation
Time frame: 3 months
Ongoing pregnancy rate
Pregnancy ongoing beyond 12 weeks gestation
Time frame: 3 months