Effect of Prolonged GnRh Agonists on Results of Intracytoplasmic Sperm Injection (ICSI ) in Endometrioma Patients

Kasr El Aini Hospital88 enrolled

Overview

Investigators compare ICSI results for endometrioma patients with or without cyst aspiration if more than 5cm \&with or without GnRh agonists for all endometrioma patients

Group 1 consists of 30 patients of endometrioma more than 5cm subdivided into: Group 1A;Cyst aspiration followed by standard long protocol in 15 patients Group 1B;Cyst aspiration followed by GnRh suppression for 3 months then standard long protocol in 15 patients Group 2 consists of 30 patients of endometrioma less than 5cm subdivided into : Group 2A;no intervention to the cyst. Standard long protocol Group 2B;GnRh suppression for 3 months then standard long protocol

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Endometrioma

Interventions

endometrioma aspirationPROCEDURE

Transvaginal ultrasound guided aspiration

GnRh agonist ( Decapeptyl )DRUG

3 monthly doses of Decapeptyl 7.5mg intramuscular

standard long stimulation protocolPROCEDURE

Decapeptyl 3.75mg in the mid luteal phase followed by human menopausal gonadotropins(HMG);fostimon, or merional injections after bleeding, doses are individualization according to each patient, monitored by follicular size \&serum estradiol.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * endometrioma patients Exclusion Criteria: * Follicle stimulating hormone(FSH)10 or more * hydrosalpinx * GnRh suppression in the last 12 months

Locations (1)

Kasrelaini Hospital

Giza, Egypt

Outcomes

Primary Outcomes

Number of patients with urine pregnancy test positive 2 weeks after embryo transfer

Time frame: 5 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.