Boric Acid in Degree 2 Furcation Defect

Government Dental College and Research Institute, Bangalore48 enrolled

Overview

The purpose of this double-masked, randomized, controlled clinical trial was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic parameters and compare this method with SRP plus placebo gel alone in patients with chronic periodontitis (CP).

Background: The purpose of this double-masked, randomized, controlled clinical trial was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic parameters and compare this method with SRP plus placebo gel alone in patients with chronic periodontitis (CP). Methods:FORTY EIGHT systemically healthy patients with CP are included in this study. They were divided into two groups: 1) SRP + 0.75% Boric acid gel (BA group); 2) SRP + Placebo gel (Placebo group). At baseline, 3 month, and 6 months after treatment, clinical measurements, including plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), clinical attachment level (CAL) and radiographic parameters intrabony defect depth (IBD), percentage change in radiographic defect depth reduction (DDR%) were assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Chronic Periodontitis With Mandibular Degree 2 Furcation Defects

Interventions

0.75 % Boric AcidDRUG

After Scaling and Root Planing placement of 0.75% Boric Acid gel in Mandibular degree 2 Furcation defect.

placeboDRUG

After Scaling and Root Planing placement of Placebo gel in Mandibular degree 2 Furcation defect.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of buccal Class II furcation defects in endodontically vital, asymptomatic mandibular first and second molars with a radiolucency in the furcation area on an intraoral periapical radiograph with probing depth (PD) ≥ 5mm and horizontal ≥ PD 3mm after phase I therapy i.e, scaling and root planing (SRP) * No history of antibiotic or periodontal therapy in the preceding 6 months Exclusion Criteria: * Systemic conditions known to affect the periodontal status * Medications known to affect the outcomes of periodontal therapy * Hematological disorders and insufficient platelet count (\<200,000/mm3) * Pregnancy/lactation * Smoking and tobacco use in any form * Immunocompromised individuals * Those having unacceptable oral hygiene (plaque index \[PI\] \>1.5) * Teeth with furcation involvement, non-vital teeth, and carious teeth indicated for restorations and mobility of at least grade II * Aggressive periodontitis

Locations (1)

Government Dental College and Research Institute

Bangalore, Karnataka, India

Outcomes

Primary Outcomes

Radiographic bone fill

assessed in percentage

Time frame: Baseline to 6 months

Secondary Outcomes

probing depth

measured in mm

Time frame: 3 and 6 months

Relative vertical attachment leve

measured in mm

Time frame: 3 and 6 months

Relative horizontal attachment level

measured in mm

Time frame: 3 and 6 months

modified sulcus bleeding index

0-3 scale

Time frame: 3 and 6 months

plaque index

0-3 scale

Time frame: 3 and 6 months

Data from ClinicalTrials.gov

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