Pioglitazone and Lumbar Bone Marrow Fat in Chronic Kidney Disease

Inclusion Criteria: * Included subjects will be those who consent to the study of Pioglitazone in ADPKD (Protocol number 1308084213). Therefore inclusion and exclusion criteria are the same as for that study. Subjects will NOT be offered participation in the bone marrow fat study till after they consent for the FDA approved study. Subjects who withdraw from the FDA approved study will be withdrawn from this protocol. Inclusion/Exclusion Criteria for NCT#02697617 * Male or female ADPKD patients aged 18-55 * eGFR at or above ≥ 50 ml/min/1.73 m2 by 4 parameter MDRD or CKD-Epiformulas * normal liver enzymes (ALT/AST) * fasting blood glucose between 70 and120 * for female patients, a willingness to use double contraception to avoid pregnancy while in study * able to give informed consent * In the opinion of the investigator, high likelihood of progressive kidney disease Exclusion Criteria: * diabetes, defined as any of the following: fasting blood sugar \> 130 times two, HgbA1C \> 7, on any blood sugar lowering medication, or past diagnosis of diabetes not occurring during pregnancy * uncontrolled hypertension, defined as systolic \> 150, diastolic \> 90 despite an attempt by physician to titrate medications * history of impaired systolic function (ejection fraction \< 50%) by previous ECHO or known ischemic cardiovascular disease * findings suggestive of a kidney disease other than ADPKD * systemic illness requiring immunosuppressive or anti-inflammatory agents * congenital absence of a kidney or history of a total nephrectomy * history of cyst reduction or partial nephrectomy * history of renal cyst aspiration within the previous year * History of bladder cancer, or gross hematuria * inability to undergo MRI due to implantable devices or foreign objects that preclude MRI * active renal transplant * allergy or sensitivity to any of the components of the test materials * institutionalized * currently pregnant or plans to become pregnant during the study