This observational epidemiologic study with nested cross-sectional and longitudinal aims will evaluate host immune response to mixed chronic infections (Helicobacter pylori, latent tuberculosis, intestinal helminthiasis) in recent US immigrants.
1750 clinically-well, adult (age 18-55 years), recent immigrants (\<2 years U.S. residence), referred through cooperating public health clinics in the Santa Clara Valley area, CA will be screened for H. pylori, helminth, and latent tuberculosis infections \["Screening" population\]. Of these 1750, 426 will be selected for more intensive study (Cohort population), 105 of whom will receive baseline endoscopy. Of those selected for the cohort, 300 are expected to complete a 9-month follow-up assessment, 75 of whom are expected to undergo a second follow-up endoscopy.
Study Type
OBSERVATIONAL
Enrollment
1,750
Santa Clara Public Health Clinics
San Jose, California, United States
Stanford University School of Medicine
Stanford, California, United States
Change in cytokine responses from baseline at 9 months in TB and H. pylori antigen-induced PBMC before and after provider managed treatment of latent TB or helminth infection
Time frame: Baseline and 9 months after treatment for either latent TB or helminth infections; analyzed after all subjects recruited (3 years of recruitment plus 9 months follow-up).
Correlation of cytokine response to TB antigens and helminths with humoral responses to infections with H. pylori.
Time frame: Assays performed when collected over three years from recruited subjects; analyzed at the end of three years.
Population prevalence of individual and joint infections with H pylori, latent tuberculosis, heminthiasis in recent immigrant to northern California
We compare prevalence of these infections in recent immigrants by geographic area
Time frame: Assays performed when collected over three years from recruited subjects; analyzed at the end of three years.
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