Open Label Study of OTO-104 in Subjects With Meniere's Disease

Inclusion Criteria includes, but is not limited to: * Subject has a diagnosis of definite unilateral Meniere's disease. * Subject agrees to maintain their current standard of care treatments for Meniere's disease while on-study. Exclusion Criteria includes, but is not limited to: * Subject has an infection in the ear, sinuses, or upper respiratory system. * Subject is pregnant or lactating. * Subject has a history of immunodeficiency disease. * Subject has active or recent (\<1 month prior to screening) middle ear disease, including but not limited to: chronic otitis media, acute otitis media, middle ear effusions, middle ear atelectasis, or cholesteatoma. * Subject has experienced an adverse reaction to intratympanic injection of steroids.