E-cigarettes and Blood Vessel Function

University of California, Los Angeles148 enrolled

Overview

Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on endothelial function and markers of oxidative stress.

Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and undergo a measure of endothelial function called brachial artery flow mediated dilatation (FMD). Additionally, oxidative stress will be measured pre and post exposure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

148

Conditions

Nicotine Dependence

Interventions

one time exposure to e-cig with nicotineOTHER

one time exposure to e-cig vapor with nicotine

one time exposure to e-cig without nicotineOTHER

one time exposure to e-cig without nicotine

one time exposure to empty e-cigOTHER

one time exposure to empty e-cig (sham control

Eligibility

Sex: ALLMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy Exclusion Criteria: * Cardiac disease * Respiratory disease * Diabetes mellitus

Locations (1)

UCaliforniaLA

Los Angeles, California, United States

Outcomes

Primary Outcomes

Flow mediated dilatation (FMD)

FMD is a measure of endothelial function

Time frame: 10 minutes after exposure

Paraoxonse

plasma oxidative stress

Time frame: less than 1 hour after exposure

Data from ClinicalTrials.gov

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