The purpose of this multicenter study is to evaluate the effectiveness and safety of dexmedetomidine combined with sufentanil for patient-controlled analgesia after caesarean section
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
225
Control Group receives normal saline bolus after delivery
Dex Group receives dexmedetomidine bolus 0.5mcg/kg after delivery
sufentanil PCA after surgery
Obstetrics & Gynecology Hospital of Fudan University
Shanghai, Shanghai Municipality, China
Sufentanil consumption
The total consumption of sufentanil during 24h after surgery are recorded.
Time frame: During 24h after surgery
Changes in pain score
Pain scores at rest and movement are evaluated with a visual analogue scale (VAS).
Time frame: At 0, 4, 8 and 24 h after surgery
Changes in Ramsay sedation score (RSS)
Sedation intensity measured with RSS is recorded at the 4, 8 and 24 h after surgery.
Time frame: At 4, 8 and 24 h after surgery
Changes in systolic blood pressure
Systolic blood pressure is recorded at 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery.
Time frame: At 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery.
Press times of analgesic pump
The total press times and invalid press times are recorded during 24h after surgery.
Time frame: During 24h after surgery
Changes in heart rate (HR)
HR is recorded at 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery.
Time frame: At 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery
Changes in saturation of blood oxygen (SpO2)
SpO2 is recorded at 0 min, 5 min, 10 min, 30 min after intervention during surgery
Time frame: At 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
sufentanil combined with dexmedetomidine PCA after surgery
Changes in diastolic blood pressure
Diastolic blood pressure is recorded at 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery.
Time frame: At 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery
Changes in mean arterial blood
Mean arterial blood pressure is recorded at 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery.
Time frame: At 0 min, 5 min, 10 min, 30 min after intervention during surgery and at 8h,24 h after surgery