Brain Sleep Deprivation MRI Effects (BEDTIME)

NYU Langone Health

Overview

The primary purpose of this study is to explore the underlying mechanisms that link sleep to Alzheimer's disease (AD), with special focus on the clearance of metabolites in the extracellular space of the brain during sleep. Subjects will wear an actigraph for 1 week to determine regular daytime activity and sleep patterns. Subjects will then undergo partial sleep deprivation followed by 4 hours of in-lab nocturnal polysomnography (NPSG). Participants will be be asked to stay awake and active all day after the partial sleep deprivation with a new actigraphy secured by a hospital band to assure participants remain awake. They will seep inside an MRI machine for 90 minutes on the following night during their usual bedtime (established by 1 week actigraphy study.) Morphologic imaging, flow imaging and diffusion kurtosis imaging (DKI) will be performed on a 3T Siemens scanner.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Conditions

Alzheimer's Disease

Interventions

ActigraphDEVICE

Participants will be asked to wear an actigraph

Eligibility

Sex: ALLMin age: 21 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age range 21-30 * Capable of giving informed consent Exclusion Criteria: * Diagnosis of any brain disease or brain damage including significant trauma, hydrocephalus, seizures, mental retardation or other serious neurological disorders (e.g. Parkinson's disease or other movement disorders). Persons with silent cortical infarcts will be excluded. White matter lesions will not be exclusions. * History of major psychiatric illness (e.g., schizophrenia, bipolar or life long history of major depression) * Conditions that alter normal sleep patterns: irregular sleep-wake rhythms (based on one week at home monitoring with actigraphy), moderate to severe periodic limb movement while you sleep (PLMS) or Obstructive Sleep Apnea (OSA). * History of claustrophobia. * BMI≥30 * Significant history of alcoholism or drug abuse. * Inability to avoid the use of alcohol or caffeine during the 48h before the MRI. * Current pregnancy or intent to become pregnant during the period of study. * Any electronic or ferromagnetic devices (e.g., pacemaker or surgical clips) that constitutes a hazard for MRI imaging. * Any medications adversely affecting cognition, blood pressure, glucose metabolism, or sleep will result in exclusion.

Locations (1)

New York University School of Medicine

New York, New York, United States

Outcomes

Primary Outcomes

Measure of Interstitial Space Volume during sleep using MRI imaging

Data will be acquired using imaging sequences that comply with federal limits regarding radiofrequency energy deposition and gradient slew rates.

Time frame: 6 Months

Secondary Outcomes

Changes in Cerebral Spinal Fluid volume measured by increases in the power of slow wave activity (SWA)

Data will be acquired using imaging sequences that comply with federal limits regarding radiofrequency energy deposition and gradient slew rates.

Time frame: 6 Months

Data from ClinicalTrials.gov

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