Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

St. Olavs Hospital21 enrolled

Overview

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression. The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Depressive Disorder Depressive Disorder, Major

Interventions

One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)

Long slow distance training (LSD)BEHAVIORAL

One training session, long slow distance training (LSD) at 70 % of the HRmax

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Moderate or severe depression (ICD10: F32-F33) Exclusion Criteria: * Bipolar disorder.

Locations (1)

St.Olavs university Hospital, Departement of Østmarka

Trondheim, Norway

Outcomes

Primary Outcomes

Change in serum brain derived neurotropic factor (BDNF)

To measure serum BDNF levels, blood samples will be taken before and after each workout session.

Time frame: 15 minutes before exercise to 5> minutes after exercise.

Secondary Outcomes

Change in affective symptoms

The positive and negative affect schedule (PANAS) .

Time frame: 15 minutes before exercise to 15> minutes after exercise.

Change in state of anxiety.

A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety.

Time frame: 15 minutes before exercise and 15> minutes after exercise.

Change in subjective exercise experience

The Subjective exercise experience scale (SEES).

Time frame: 15 minutes before exercise to 15> minutes after exercise.

Maximal oxygen uptake

Time frame: Baseline

Maximal Heart rate

Time frame: Baseline

Data from ClinicalTrials.gov

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