It is suspected that zika virus infection during pregnancy is associated with microcephaly. The objective of this study is to investigate the occurrence of rash accompanied by three or more dengue-like signs and symptoms during pregnancy is related to the microcephaly using the case-control design.
The investigators will carry out a case-control study among mothers who delivered their babies at Nossa Senhora de Lourdes maternity hospital located in Aracaju, state of Sergipe, Brazil from September 1, 2015 through January 5, 2016. Data sources for the phase I of the study will consist of medical records review and a standard questionnaire applied by telephone to collect information about demographic features, clinical signs and symptoms, and the duration and severity of the illness. Phase II will include dengue, chikungunya and dengue serologic test results as secondary outcome, if available. The objective of this study is to investigate the occurrence of rash accompanied by three or more dengue-like signs and symptoms during pregnancy is related to the microcephaly using the case-control design
Study Type
OBSERVATIONAL
Enrollment
110
Questionary with clinical, demographic and behavior outcomes at the pregnancy period
Sabin laboratory
Brasília, Federal District, Brazil
Zika virus infection clinical outcomes during pregnancy
acute onset of generalized rash together with three of the following symptoms: Conjunctivitis, arthralgia, mild-fever or periarticular edema.
Time frame: From September 1, 2015 through January 5, 2016
zika virus serology
If available, zika virus serology will be performed
Time frame: march, 2016 through July 5, 2016
Chikungunya virus serology
If available, chikungunya virus serology will be performed
Time frame: march, 2016 through July 5, 2016
Dengue virus serology
If available, Dengue virus serology will be performed
Time frame: march, 2016 through July 5, 2016
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