To investigate the effect of Dipeptidyl Peptidase 4 Inhibition on wound healing in patients with diabetic foot ulcers, the investigators randomly divided the participants into two groups: saxagliptin with regular treatment group，placebo with regular treatment group. The clinical data are collected at the given time point. This study aimed to observe the potential protective effect of DPP4i on diabetic ulcers.
Groups: Diabetic ulcers, saxagliptin + Regular treatment. Diabetic ulcers, placebo + Regular treatment. Time Point: Initial treatment; Post-treatment ( 1w ); Post-treatment ( 2w ); Post-treatment ( 4w ); Completely healed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Qualifying Period: Participants will receive regular treatment for diabetic ulcer without DPP4i. Treatment Period: Participants will receive saxagliptin with regular treatment
Qualifying Period: Participants will receive regular treatment for diabetic ulcer without DPP4i. Treatment Period: Participants will receive placebo with regular treatment
The Second Affiliated Hospital, Third Military Medical University
Chongqing, Chongqing Municipality, China
RECRUITINGCompletely healing time of the participants'target ulcer during the treatment period.
Complete ulcer closure is defined as 100% skin re-epithelialization
Time frame: 16 weeks
Proportion of participants with complete healing during the treatment period.
Complete ulcer closure is defined as 100% skin re-epithelialization
Time frame: 16 weeks
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