Lumefantrine in Venous Plasma Versus Dried Capillary Blood Spot

Inclusion Criteria: * Absence of current drug treatment (except hormonal contraception, an additional barrier method is strongly advised) * 12-lead ECG without significant abnormalities * The subject understands the procedures, agrees to participate and is willing to give written informed consent * The subject agrees to be available for at least 5 blood sampling after drug administration, at scheduled time points. Exclusion Criteria: * History of any major medical disorder * Any recent acute illness which could expose the subject to a higher risk or might confound the results of the study * Current pregnancy or breast-feeding * Congenital prolongation of the QT interval (e.g., long QT syndrome) or any other clinical condition known to prolong the corrected QT interval * Family history of congenital prolongation of the QT interval or sudden death * Known disturbances of electrolyte balance * Known liver disorder of any type, even if no medical treatment is needed. Gilbert syndrome will be tolerated, if mild * Treatment in the previous three months with any drug known to have well-defined potential for toxicity to a major organ * History of hypersensitivity to any component of the drug * History of hypersensitivity to any drug if considered as serious * History of alcohol or drug abuse * Present consumption of a large quantity of alcohol or wine (\>0.5 L wine/day) or equivalent. Consumption of reasonable amount of wine (0.3 L) or of beer is acceptable, except between Day -1 to Day 3 of drug administration * Use of any medication the week prior to study or as based on 5 plasma half-life rule and up to 48 hours post drug administration * Participation in a clinical trial in the previous 3 months unless no treatment provided and low amount of blood collected * Occupation which might interfere with visits and blood sampling during the study * Psychological status which could have an impact on subject's ability to give informed consent * Any feature of subject's medical history or present condition which, in the investigator's opinion, could confound the results of the study, complicate their interpretation or represent a potential risk for the subject