Study Objectives: 1. Determine the correlation between quantitative muscle ultrasound (QMUS), electrical impedance myography (EIM) and currently accepted measures of physical function. 2. Determine the reliability of EIM measures performed in the home through use of a hand held device. 3. Determine if QMUS and EIM can detect pre-clinical changes in Pompe disease.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DEVICE_FEASIBILITY
Masking
SINGLE
Enrollment
25
Ultrasound images of limb muscles will be collected.
A painless current passes through the skin and surface electrodes are used to record the impedance through muscle.
Duke University Medical Center
Durham, North Carolina, United States
Percent change in muscle ultrasound echointensity as compared to baseline
Time frame: Baseline, 1-2 years
Percent change in muscle electrical impedance myography as compared to baseline
Time frame: Baseline, 1-2 years
Inter-rater reliability of muscle ultrasound and electrical impedance myography measures
Time frame: 1-2 years
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