A Study to Evaluate Efficacy and Safety of a Fixed Combination Ocular Insert in Participants With Open-angle Glaucoma or Ocular Hypertension

Key Inclusion Criteria: * Written informed consent * At least 18 years of age * Diagnosis in both eyes of either primary open-angle glaucoma (POAG) or ocular hypertension * Best corrected-distance visual acuity score equivalent to 20/80 or better * Stable visual field * Central corneal thickness between 490 - 620 micrometers Inclusion Criteria at the Randomization Visit: * IOP for each eye is ≥ 23 mmHg at T=0hr, ≥ 20 mmHg at T=4hr and T=8hr. * Inter-eye IOP difference of ≤ 5.0 mmHg at T=0hr, T=4hr and T=8hr. * IOP for each eye is ≤ 30 mmHg at T=0hr, T=4hr and T=8hr. Key Exclusion Criteria: * Any known contraindication to prostaglandin analog (latanoprost, travoprost, bimatoprost, tafluprost) or timolol * A cardiac or pulmonary condition that in the opinion of the Investigator would contraindicate the use of a topical beta-blocker * Use of any agents known to have a substantial effect on IOP during planned study period (e.g. beta-blockers) * Cup-to-disc ratio of greater than 0.8 * Significant risk of angle closure due to pupil dilation, defined as a Shaffer classification of less than Grade 2 based on gonioscopy * Ocular, orbital, and/or eyelid surgery of any type within the past six (6) months from screening date * Laser surgery for glaucoma / ocular hypertension on one (1) or both eyes within the last six (6) months * Past history of any incisional surgery for glaucoma at any time * Past history of corneal refractive surgery * Corneal abnormalities that would interfere with accurate IOP readings with an applanation tonometer * Current participation in an investigational drug or device study or participation in such a study within 7 days of Screening * Inability to adequately evaluate the retina * Subjects who will require contact lens use during the study period. * Subjects who currently have punctal occlusion * Pregnant, lactating or of child-bearing potential and not using a medically acceptable form of birth control