The indications for mechanical ventilation (MV) include excessive work of breathing, with or without evidence of respiratory muscle fatigue. The setting of the MV is still a challenge because it is based on criteria understudied, often subjective and observer-dependent. Despite several studies, to our knowledge has never been done before is the precise definition of the optimal range of ventilatory support. Novel and recognizable diagnostic techniques will be applied. No single parameter of the breathing pattern has good accuracy for the adjustment of ventilatory support. Non-invasive measures such as P0.1 and rate of muscle relaxation may have good accuracy for the adjustment of ventilatory support.
Use of excessive pressure support
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
27
The pressure support of the patient was changed form the baseline to 20 cmH20 and then stepwise decreased to 2 cmH20,
Hospital Clinicas Sao Paulo
São Paulo, São Paulo, Brazil
Hearth Institute - University of Sao Paulo
São Paulo, São Paulo, Brazil
Measuring muscular force
Muscular force measured by inspiratory force in centimeters of water (cmH2O)
Time frame: From the baseline ventilation to the minimum level of pressure support. Around 3 hours
Measuring inspiratory drive
Inspiratory drive measured in cmH2O in the first 100 milliseconds of the inspiration
Time frame: From the baseline ventilation to the minimum level of pressure support. Around 3 hours
Measuring endurance
Endurance measured by the maximal relaxation rate (cmH2O/10ms)
Time frame: From the baseline ventilation to the minimum level of pressure support. Around 3 hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.