The purpose of this study is to determine whether cervical lymph node dissection is necessarily performed in the presence of early-stage oral squamous cell carcinoma.
Oral squamous cell carcinoma is the most common malignant tumor of oral and maxillofacial region, and prone to early cervical lymph node metastases. Lymphatic spread is associated with increased risk of loco-regional recurrence, therefore, the identification of lymph node metastases preoperatively is very important for the optimal surgical therapy. Recently, cervical lymph node dissection(CLND) is performed in the presence of oral squamous cell carcinoma. However, whether cervical lymph node dissection is necessarily performed in the presence of early-stage oral squamous cell carcinoma is still controversial. CLND will represent over-treatment in some case of early-stage oral squamous cell carcinoma. Therefore, How to accurately predict whether a patient should be performed CLND is important. Our previous study show that tumor budding is closely related to lymphatic spread in the oral squamous cell carcinoma. The purpose of this study is to find that whether the tumor budding guide the individualized surgical planning of early-stage oral squamous cell carcinoma.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
524
Resection for primary lesion and cervical lymph node dissection are performed in the early-stage oral squamous cell carcinoma.
Only resection for primary lesion is performed in the early-stage oral squamous cell carcinoma.
Guanghua School of Stomatolagy, Hospital of Stomatology Sun Yat-sen University
Guangzhou, Guangdong, China
RECRUITINGFive-year survival rate
The time from the first operation to death was recorded
Time frame: After the first year, review every three months at a time；The next four years, review every six months at a time.
Disease free survival
The time from the start of surgery to the discovery of the first cervical lymphatic metastases
Time frame: After the first year, review every three months at a time；The next four years, review every six months at a time.
Recurrence rate
To investigate the local recurrence rate and the recurrence rate of cervical lymphatic metastasis.
Time frame: After the first year, review every three months at a time；The next four years, review every six months at a time.
Evaluation of quality of life
Complete the University of Washington Quality of Life Form (UW-QOL) To understand the quality of life of patients after surgery.
Time frame: After the first year, review every three months at a time；The next four years, review every six months at a time.
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