Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic Surgery

Yonsei University202 enrolled

Overview

Postoperative nausea and vomiting (PONV) is related with extended hospital day and risk factor of aspiration pneumonia. Postoperative patient controlled intravenous analgesia is related with postoperative nausea and vomiting. Selective 5-HT3 antagonist, Palonosetron, is the most recent medication for prevention of PONV. Purpose of our study is comparison of PONV preventive effect of palonosetron and combination of palonosetron and dexamethasone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

202

Conditions

Orthopedic Surgery

Interventions

palonosetronDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who are undergoing minor orthopedic surgery. * IV patient controlled analgesia Exclusion Criteria: * 1\. minority (0\~19 year) * patients who are belongs to ASA class 3 or more, and have underlying complicated cardiovascular or psychological disease. * Steroid medication * Diabetes Mellitus medication

Locations (1)

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

incidence of clinically significant PONV with PONV impact scale

Time frame: 72 hours

Data from ClinicalTrials.gov

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