Physiologic Study of Cerebral Perfusion

Centre de recherche du Centre hospitalier universitaire de Sherbrooke22 enrolled

Overview

The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Cerebral Perfusion Pressure Vasopressor Agents Shock Magnetic Resonance Imaging (MRI), Functional

Interventions

Higher doses of vasopressor therapy for a MAP of 75 mmHgDRUG

Lower doses of vasopressor therapy for a MAP of 65 mmHgDRUG

Propofol for light sedationDRUG

Propofol for light sedation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Healthy Subjects : * Inclusion criteria : * being over 18 years old * Exclusion criterias : * having a positive serum pregnancy test * having a contraindication to MRI * having a contraindication to receive light sedation with propofol * suffering of claustrophobia or of anxiety disorder Shock Subjects : * Inclusion criterias : * being over 18 years old * being hospitalized to the medical intensive care unit of the CHUS Fleurimont * being in a stabilized shock state, primarily of distributive etiology * having received an appropriate fluid resuscitation, as judged by the attending physician * Exclusion criterias : * having a different primary etiology of shock than distributive (cardiogenic, hypovolemic, obstructive) * needing vasopressor therapy as the result of extracorporeal circulation * having known cerebral lesions * having an intra-aortic balloon pump * being in a palliative or near end-of-life situation * having a contraindication to MRI * suffering of claustrophobia or of anxiety disorder

Locations (1)

Université de Sherbrooke

Sherbrooke, Quebec, Canada

Outcomes

Primary Outcomes

Global and regional cerebral blood flow

Cerebral blood flow will be measured by the arterial spin labeling technique (ASL) which provides information expressed in mL/100g/min. Using 3-T MRI technology,we will first acquire T1 images of the brain and sub-regions of interest. Thereafter, ASL sequences will be acquired in contiguous slices. The procedure will be followed on sedation and off sedation for healthy volunteers (in random order) and at mean arterial pressure of 65 mmHg and 75 mmHg (in random order) in patients receiving vasopressor therapy.

Time frame: Within 15 minutes of intervention initiation

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.