Effect of a Yoghurt Containing Four Probiotic Lactobacillus Strains on Bacterial Vaginosis

Inclusion Criteria: To be enrolled, the following criteria have to be fulfilled: 1. Woman aged ≥ 18 years with stable menstrual cycle or postmenopausal women 2. Newly diagnosed bacterial vaginosis based on Amsel criteria 3. Complies with a standard oral antibiotic treatment with Metronidazol for 7 days, 2 x 500mg/day) 4. Willing to consume for 4 weeks the study product two times daily 5. Willingness to abstain from food and supplements containing probiotics, prebiotics and other fermented products as well as dietary supplements 6. Not in menses at the time of the first examination at the gynaecologist (G1) 7. Written informed consent Exclusion Criteria: 1. Subjects currently enrolled in another clinical study. 2. Subjects having finished another clinical study within the last 4 weeks before inclusion. 3. Infection caused by Chlamydia trachomatis 4. Infection caused by Neisseria gonorrhoea 5. Infection caused by Trichomonas vaginalis 6. Infection caused by Candida albicans or other mycosis 7. Leucocytes present in the vaginal smear 8. PAP-testing ≥ 3 (anamnestically) 9. Vulvovaginal inflammation as macroscopically identified by the gynaecologist 10. Dyspareunia 11. Pregnancy and breastfeeding 12. Chemically based contraceptives (e.g. suppositories, salves, foam, gel) 13. Irregular cycles (e.g. polymenorrhoea, metrorrhagia) 14. Dysuria 15. Infection of the urinary tract 16. Chronic or sporadic abdominal pain with exception of dysmenorrhoea 17. Any ano-rectal infection, disease, surgery in the medical history or current 18. Anus praeter 19. Hypersensitivity, allergy or idiosyncratic reaction to metronidazole or any similar active substances. 20. Hypersensitivity, allergy or idiosyncratic reaction to any component of the yoghurt (e.g. lactose intolerance, allergy against milk protein) 21. Any disease or condition which might compromise significantly the hematopoietic, renal, endocrine, pulmonary, hepatic, gastrointestinal, cardiovascular, immunological, central nervous, dermatological or any other body system with the exception of the conditions defined by the inclusion criteria. 22. History of hepatitis B and C 23. History of HIV infection 24. Regular medical treatment including OTC, which may have impact on the study aims (e.g. probiotics, antibiotic drugs, laxatives etc.) 25. Major cognitive or psychiatric disorders 26. Subjects who are scheduled to undergo hospitalization during the study period 27. Eating disorders (e.g. anorexia, bulimia) or special diets (e.g. vegan, vegetarian) 28. Present drug abuse or alcoholism, reformed alcoholic 29. Legal incapacity