Clinical Pilot Trial on the Effect of a Probiotic Fermented Drink on Antibiotic-associated Diarrhea (AAD)

Inclusion Criteria: * Individuals, both genders, aged ≥ 18 y * Helicobacter p. infected individuals, to which eradication therapy has been recommended by gastroenterologists * Willingness to undergo the Helicobacter p. eradication therapy * Willingness to abstain from food and supplements containing probiotics, prebiotics and fermented products except the study product * Written informed consent Exclusion Criteria: * Subjects currently enrolled in another interventional trial * subjects having finished another interventional trial within the last 4 weeks before inclusion * incapacity to comply with the study protocol * allergy or hypersensitivity to any component of the test product (allergy against milk protein) * allergy or hypersensitivity to any component of the eradication therapy (e.g. penicillin allergy) * acute GIT infections * chronic inflammatory bowel diseases (IBD) * irritable bowel syndrome (IBS) * any episode of diarrhea according to WHO criteria during the last 4 weeks before inclusion * history of lactose intolerance * severe chronic disease (cancer, malabsorption, malnutrition, severe chronic inflammatory diseases (except chronic gastritis), renal, hepatic or cardiac diseases, artificial cardiac valve, COPD, respiratory insufficiency) * history of active or persistent hepatitis B and C * known congenital, acquired or iatrogenic immunodeficiency (e.g. HIV, chemotherapy, immunosuppression) * systemic treatment with antibiotics during the last 4 weeks before inclusion * systemic treatment likely influencing absorption, metabolism and excretion of food ingredients (metoclopramide, laxatives, body weight management and/or medication etc.) * systemic treatment likely interfering or influencing effectiveness of the eradication drugs used e.g. ergotamine, statins, clopidogrel * regular medical treatment including OTC, which may have impact on the study aims (e.g. probiotics, antibiotic drugs, laxatives etc.) * severe neurological, cognitive or psychiatric diseases * surgery or intervention requiring general anaesthesia within 2 months before the study * vegan * eating disorders (e.g. anorexia, bulimia) * present alcohol and drug abuse * pregnancy or lactation * legal incapacity * blood parameters: * Hb \< 12 g/dL * liver transaminases (ALT, AST) \> 2-fold increased * serum creatinine out of the normal range * subjects who are scheduled to undergo hospitalization during the study period