Antibacterial Effectiveness of Two Root Canal Irrigants

University of Oslo49 enrolled

Overview

The aim of this randomized clinical trial is to compare the antibacterial effects of 1% sodium hypochlorite (NaOCl) and 2% chlorhexidine gluconate (CHX) during retreatment of teeth with apical periodontitis (AP).

Root canal-treated teeth with AP were randomly distributed in two groups according to the irrigant used. After removal of the previous filling material, bacteriological samples were taken from the canals before (S1) and after chemomechanical preparation using either NaOCl or CHX (S2), and after calcium hydroxide medication for 2-3 weeks (S3). 16S rRNA gene-based real-time qPCR was performed to detect and quantify total bacteria, Streptococcus species and Enterococcus faecalis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Periapical Periodontitis

Interventions

Retreatment of root-filled teeth with infectionPROCEDURE

Root-filled teeth with infection are being treated with either 1% NaOCl or 2% CHX as disinfection irrigation solution.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 95 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of apical periodontitis in a root-filled tooth assessed by radiography. Exclusion Criteria: * Presence of gross carious lesions in the diagnosed tooth, * Presence of fractures involving the periodontium of the diagnosed tooth, * Presence of periodontal pockets more than 4 mm deep in the diagnosed tooth, * Diagnosis of diabetes, * Diagnosis of HIV infection, * Other immunocompromising disease, * Antibiotic therapy within the previous 3 months.

Locations (1)

University of Oslo

Oslo, Oslo, Norway

Outcomes

Primary Outcomes

Periapical radiolucency (PAI- and Friedman-scores)

Time frame: 12 months

Secondary Outcomes

Bacterial load assessed by qPCR

Time frame: 21 days

Pyrosequencing of species found before and after the intervention

Time frame: 21 days

Data from ClinicalTrials.gov

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