The Effect of Vitamin D Supplementation on the Pulmonary Functions of Adult Asthmatic Egyptian Patients

Cairo University82 enrolled

Overview

This study evaluates the effect of vitamin D supplementation in the form of Alfacalcidol on the the pulmonary function of adult asthmatic Egyptian patients

Asthmatic patients are recruited and divided into two groups. One receives Alfacalcidol beside their normal medications while the other acts as a control group receiving the normal asthma medication. Both groups are followed up for four months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Asthma

Interventions

AlfacalcidolDIETARY_SUPPLEMENT

1-alpha hydroxy cholecalciferol 1 mcg

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients diagnosed with asthma 2. Non-smokers Exclusion Criteria: 1. Liver impairment 2. Kidney impairment 3. Patients receiving digoxin 4. Known hypersensitivity to 1α-hydroxyvitamin D3, vitamin D or any of its analogues and derivatives 5. Hypercalcaemia 6. Hyperphosphatemia 7. Pregnancy and breast-feeding 8. Patients on nutritional supplements with a potential effect on 25(OH)D serum concentrations 9. Had a History of stones in the urinary tract or diseases of calcium or bone metabolism

Outcomes

Primary Outcomes

forced expiratory volume % predicted values

Time frame: 4 months

Data from ClinicalTrials.gov

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