Paravertebral Block (PVB) Combined Pectoral Musculature Blocks for Modified Radical Mastectomy (MRM)

Sun Yat-sen University100 enrolled

Overview

Previous studies have shown that PVB reduces pain and postoperative nausea and vomiting after breast cancer surgery when used in addition to general anesthesia or sedation. However, major breast cancer surgery involves areas beyond the breast tissue, such as pectoral musculature.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Mastectomy, Modified Radical

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The American Society of Anesthesiologists (ASA) Physical Status classification I to III * 20 - 75 years of age * female gender Exclusion Criteria: * body mass index (BMI) ≥ 35 kg/m2 * modified radical mastectomy not performed by the single surgeon (Ben Long Yu) * anesthesia not performed by the single anesthesiologist (Nai Liang Li)

Outcomes

Primary Outcomes

intraoperative sedation requirement

target controlled infusion (TCI) propofol driven by the Schnider model in effect site control titrated to reach conscious sedation defined as Observer Assessment of Alertness/Sedation score of 2 to 3

Time frame: during operation

Secondary Outcomes

time to first request of analgesics

Time frame: postoperative 12 hours

postoperative analgesic requirement

Time frame: postoperation to discharge

side effects

Time frame: postoperation to within 24 hours after discharge

Data from ClinicalTrials.gov

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