Study of A Special Vessel Subtype in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture

Second Affiliated Hospital of Soochow University30 enrolled

Overview

RATIONALE: Collecting and storing bone samples from patients with osteoporotic and nonosteoporotic fracture to study a special vessel subtype in the laboratory may help surgeon learn more about the relationship between bone mineral density (BMD) and a special vessel subtype (type H vessel). PURPOSE: This research study is looking at changes of a special vessel subtype in bone samples from patients with osteoporotic and nonosteoporotic fracture.

OBJECTIVES: 1. Establish type H vessel in bone specimen in patients with hip fracture. 2. Explore the correlation of BMD and type H vessel. OUTLINE: 1. Collect human bone specimens from patients with Osteoporotic and Nonosteoporotic Fracture. 2. Provide a repository for storage of tissue and make these specimens available for approved projects by laboratory-based investigators. 3. Observe the type H vessel in bone slice by immunofluorescence staining. 4. Collect clinical data on these patients including bone mineral density. 5. Investigate the relationship between BMD and type H vessel.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Femoral Neck Fractures

Interventions

total hip arthroplasty or proximal femoral nailsPROCEDURE

Bone samples from Hip fracture were collected when total hip arthroplasty or proximal femoral nails was performed.

Eligibility

Sex: FEMALEMin age: 60 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Ages Eligible for Study: 65-75 Years 2. Genders Eligible for Study: Woman 3. Accepts Healthy Volunteers: NO 4. Study Population: Female patients with hip fracture. - Exclusion Criteria: 1. Malignancy or benign ovarian cysts 2. Known chronic or systemic diseases 3. Hormone therapy in the previous 3 months 4. Bone metabolism and drug therapy

Locations (1)

Second Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Outcomes

Primary Outcomes

The area of a special vessel subtype in human bone samples

Bone samples were fixed in 4% PFA, decalcified, dehydrated, embedded and immunofluorescent staining for 3 months. Calculate the proportion of the special vessel of total vessel.

Time frame: 3 months

Secondary Outcomes

The value of bone mineral density

Bone mineral density was measured by double energy X-ray absorptiometer (DXA) in a week before surgery.

Time frame: 1 week

Correlation of of bone mineral density and area of a special vessel subtype in human bone

Calculate correlation coefficient of BMD and type H vessel in human bone samples in 2 months.

Time frame: 2 months

Data from ClinicalTrials.gov

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