Detection of KRAS, NRAS et BRAF Mutations in Plasma Circulating DNA From Patients With Metastatic Colorectal Cancer

Inclusion Criteria: * Adult subjects with newly diagnosed, anti EGFR treatment naïve metastatic colorectal cancer * Standard of Care RAS/RAF tests performed on FFPE tumor sample as part of routine * Patient information and written informed consent form signed * Patient must be affiliated to a social security system * Age : 18 years and older Exclusion Criteria: * Patient bearing non-metastatic colorectal cancer * Patient with local relapse only * Patient with exclusive nodal metastases * Patient whose health contraindicates a 30 ml blood sample * Blood transfusion within 1 week prior blood collection * Patient having received any chemotherapy or / and radiotherapy within 15 days prior to blood collection * History of another primary cancer within the last 5 years, with the exception of non-melanomatous skin cancer and carcinoma in situ of the cervix * Persons deprived of liberty or under supervision