Effects of Acutely Elevated Afterload on Left Ventricular Contractility and Relaxation

University of Luebeck20 enrolled

Overview

Aim of the study is to assess the effects of abruptly increased afterload on left ventricular contractility and relaxation in patients with heart failure with preserved ejection fraction (HFPEF), patients with heart failure with reduced ejection fraction (HFREF), and patients without HFPEF or HFREF.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Heart Failure

Interventions

Conductance catheterDEVICE

Continuous online measurements of left ventricular pressure and volume using conductance catheters

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical indication for left and right heart catheterization * HFPEF (Group 1) OR HFREF (Group 2) OR absent echocardiographic evidence of HFREF OR HFPEF(Group 3) AND * Sinus rhythm during invasive measurements * Age ≥18 years * Negative pregnancy test in women with childbearing potential * Written informed consent Exclusion Criteria: * Acute coronary syndrome * Acute myocardial infarction \<6 months * Planned cardiac surgery or cardiovascular intervention within 6 months following inclusion * Valvular heart disease \>2° * Severe comorbidities with limited life expectancy \<12 months * Precapillary pulmonary hypertension * Participation in another trial

Locations (1)

Universitätsklinikum Schleswig-Holstein

Lübeck, Schleswig-Holstein, Germany

Outcomes

Primary Outcomes

Hemodynamic parameter 1: Changes in contractility assessed by the end-systolic pressure-volume relationship

Changes in contractility after handgrip exercise assessed by the end-systolic pressure-volume relationship

Time frame: Day 1

Secondary Outcomes

Hemodynamic parameter 2: Changes in contractility assessed by the peak power index

Changes in contractility after handgrip exercise assessed by the peak power index

Time frame: Day 1

Hemodynamic parameter 3: Changes in relaxation assessed by the relaxation constant "tau"

Changes in relaxation after handgrip exercise assessed by the relaxation constant "tau"

Time frame: Day 1

Functional parameter: Changes in ejection fraction

Changes in ejection fraction after handgrip exercise assessed by echocardiography

Time frame: Day 1

Data from ClinicalTrials.gov

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