Cerebral Hemodynamics in Sleep Disorders

Yi Yang300 enrolled

Overview

The purpose of this study is to determine the relationship between sleep disorders and cerebral hemodynamics.

Sleep disorders continue to be the most unrecognized modifiable risk factor for stroke. The relationship between sleep disorders and vascular risk factors and stroke has been well-documented but not fully understood. The investigators hypothesize hemodynamics impairment to be its potential mechanism. It has been reported that sleep-related breathing disorder, a type of sleep disorders, contributed as a risk factor for stroke through hemodynamic and hematologic changes. The purpose of this study is to determine the relationship between different kind of sleep disorders and cerebral hemodynamics, including OSHAS, RLS, RBD, narcolepsy, etc. The dynamic cerebral auto-regulation (dCA) and Transcranial Doppler (TCD) will be used to evaluate cerebral hemodynamics.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Sleep Disorders, Intrinsic

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with sleep disorders * meet the Diagnostic Criteria for Sleep Dyssomnias * sufficient bilateral temporal bone windows for insonation of the MCA Exclusion Criteria: * middle cerebral artery (MCA) and/or other intracranial and/or extracranial major vascular 4 stenosis/occlusion, as diagnosed by a transcranial Doppler * having a prior symptomatic cerebral vascular disease * current arrhythmia, hyperthyroidism, anemia and unstable blood pressure, which may undermine hemodynamic stability * inability to cooperate sufficiently to complete the dCA examination

Locations (1)

First Hospital of Jilin University

Changchun, Jilin, China

Outcomes

Primary Outcomes

phase difference(PD) in degree

A dynamic cerebral auto-regulation parameter derived from transfer function analysis.Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the autoregulatory parameters.

Time frame: 6 months

the rate of recovery of cerebral blood flow velocity

A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as outcome 1

Time frame: 6 months

gain in cm/s/mmHg

A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as outcome 1

Time frame: 6 months

Secondary Outcomes

mean MCA blood flow velocity (mCBFV) changes from supine to upright position

Time frame: 6 months

pulsatility index (PI) changes from supine to upright position

Time frame: 6 months

resistance index (RI) changes from supine to upright position

Time frame: 6 months

Data from ClinicalTrials.gov

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