Assisted Hatching Versus Endometrial Scratch in Recurrent Implantation Failure

Kasr El Aini Hospital300 enrolled

Overview

300 recurrent implantation failure patients will be alternatively assigned to assisted hatching , endometrial scratch , and no treatment ,100 patients in each group

Group 1 consists of 100 patients will undergo endometrial scratch followed by controlled ovarian hyperstimulation Group 2 consists of 100 patients will undergo controlled ovarian hyperstimulation\& assisted hatching Group 3 consists of 100 patients will undergo controlled ovarian hyperstimulation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

300

Conditions

Recurrent Implantation Failure

Interventions

endometrial scratchPROCEDURE

midluteal endometrial scratch using Novak curette under general anesthesia in the cycle preceding stimulation

assisted hatchingPROCEDURE

using Octax laser 20120644-laser 5452

controlled ovarian hyperstimulationPROCEDURE

using merional\&/ or fostimon doses individualized as judged by patient age \& ovarian reserve \& monitored by follicular size \& serum estradiol

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * recurrent implantation failure * normal uterine cavity by transvaginal ultrasound Exclusion Criteria: * endometrial polyp or fibroid distorting the endometrium * hydrosalpinx * preimplantation genetic diagnosis * severe male factor

Outcomes

Primary Outcomes

number of patients with positive pregnancy test

Time frame: 2 months

Central Contacts

suzy abdelaziz, lecturer

CONTACT

01003726195 suzyabdelaziz92@gmail.com

Data from ClinicalTrials.gov

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