Study of Galunisertib in Healthy Participants

Inclusion Criteria: * Are overtly healthy male or female Japanese or non-Japanese participants, as determined by medical history and physical examination. * Male participants: Must agree to use a reliable method of birth control for 12 weeks after receiving the dose of study drug, OR be at least 6 weeks post-vasectomy with documentation of sperm-free ejaculate. * Female participants: Women not of child-bearing potential may participate, and include those who are: * Infertile due to surgical sterilization; or * Postmenopausal. * All female participants must test negative for pregnancy at screening. * Have a body mass index (BMI) of 18.5 to 32.0 kilogram per meter square (kg/m²), inclusive at screening. * Have clinical laboratory test results within normal reference range. * Are able and willing to give signed informed consent. Exclusion Criteria: * Have participated, within the last 3 months, in a clinical trial involving an Investigational Product (IP). If the previous IP has a long half-life, 3 months should have passed. * Have known allergies to galunisertib-related compounds or any components of the formulation, or history of significant atopy. * Have a personal or family history of long QT syndrome, heart failure, hypokalemia, or sudden death. * Have a personal history of unexplained syncope within the last year. * Have an abnormality in the 12-lead electrocardiogram (ECG) that, in the opinion of the investigator, increases the risks associated with participating in the study or affects or confounds the corrected QT (QTc) analysis (the ECG waveform morphology or rhythm are incompatible with reliable measurement of ECG intervals), or have QTcF greater than (\>) 450 milliseconds (msec). * Have an abnormal blood pressure as determined by the investigator. * Have a history or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the IP; or of interfering with the interpretation of data. * Have serum magnesium and potassium values outside of the normal reference range. * Show evidence of human immunodeficiency virus (HIV) infection, hepatitis C or hepatitis B. * Intend to use over-the-counter or prescription medication (including herbal medications) within 14 days prior to dosing. * Have donated blood of more than 500 milliliter (mL) within the last month * Have an average weekly alcohol intake that exceeds 21 units per week (males) and 14 units per week (females).