Self-reported healthy participants (n=150) aged 30-65 years with 18.5 kg/m\^2 ≤ BMI \< 30 kg/m\^2 were randomly assigned into three groups: a low linoleic acid (LA, 18:2n-6) group (n=50) replaced 10 mL soy oil with one apple; a medium LA group (control group, n=50) maintained usual food intake; a high LA group (n=50) reduced 1/3 cup of cooked refined rice and consumed 9.9g of soy oil capsules daily as a supplement. Plasma fatty acids and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity were measured at baseline and 8 week alongside other cardiovascular disease risk factors.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
150
Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University.
Seoul, South Korea
Change in Lp-PLA2 activity (nmol/mL/min)
Time frame: At baseline and end of each 8-week diet period
Change in total cholesterol (mg/dL)
Time frame: At baseline and end of each 8-week diet period
Change in LDL cholesterol (mg/dL)
Lipids and lipoproteins, such as total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, Apo A-I, Apo B
Time frame: At baseline and end of each 8-week diet period
Change in HDL cholesterol (mg/dL)
Time frame: At baseline and end of each 8-week diet period
Change in triglyceride (mg/dL)
Time frame: At baseline and end of each 8-week diet period
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