Effects of Induced Moderate HYPOthermia on Mortality in Cardiogenic Shock Patients Rescued by Veno-arterial ExtraCorporeal Membrane Oxygenation (ECMO)

All-cause mortality

Evaluation of the impact of moderate hypothermia on mortality during hospitalization and up to 180 days

Time frame: Hour 48, Day 7, Day 60, day 180

Venous Arterial ECMO duration

Evaluation of the impact of moderate hypothermia on VA-ECMO weaning time

Time frame: up to 180 days (from date of randomization until ECMO weaning)

Death

Evaluation of the impact of moderate hypothermia on adverse cardiovascular events. Composite endpoint of death, cardiac transplant, escalation to Left Ventricular Assist Device, stroke (cf secondary outcome n° 4, 5;6;7)

Time frame: day 30, Day 60, Day 180

cardiac transplant

Evaluation of the impact of moderate hypothermia on adverse cardiovascular events. Composite endpoint of death, cardiac transplant, escalation to Left Ventricular Assist Device, stroke (cf secondary outcome n° 4, 5;6;7)

Time frame: day 30, Day 60, Day 180

escalation to Left Ventricular Assist Device

Evaluation of the impact of moderate hypothermia on adverse cardiovascular events. Composite endpoint of death, cardiac transplant, escalation to Left Ventricular Assist Device, stroke (cf secondary outcome n° 4, 5;6;7)

Time frame: day 30, Day 60, Day180

Stroke

Evaluation of the impact of moderate hypothermia on adverse cardiovascular events. Composite endpoint of death, cardiac transplant, escalation to Left Ventricular Assist Device, stroke (cf secondary outcome n° 4, 5;6;7)

Time frame: Day 30, Day 60, Day 180

Cumulated amount of administered fluids

Evaluation of the impact of moderate hypothermia on necessity of fluid

Time frame: up to 180 days (from date of randomization until ECMO weaning)

Cumulated amount of vasopressors use

Evaluation of the impact of moderate hypothermia on necessity of vasopressor (norepinephrine, epinephrine)

Time frame: up to 180 days (from date of randomization until ECMO weaning)

Lactate

Evaluation of the impact of moderate hypothermia on lactate clearance

Time frame: up to 180 days (from date of randomization until ECMO weaning)

SOFA score

Evaluation of the impact of moderate hypothermia on duration of organ failure

Time frame: from baseline until Day 30

Mechanical ventilation

Evaluation of the impact of moderate hypothermia on mechanical ventilation support use

Time frame: baseline, day 30, day 60 and day 180

Renal replacement therapy

Evaluation of the impact of moderate hypothermia on renal replacement therapy use

Time frame: from baseline until day 30, day 60, day 180

Intensive care unit stay

Evaluation of the impact of moderate hypothermia on duration of ICU stay

Time frame: Day 30; Day 60; Day 180

hospitalization stay

Evaluation of the impact of moderate hypothermia on duration of total hospitalization

Time frame: Day 30; Day 60; Day 180

bleeding complications

Evaluation of the impact of moderate hypothermia on the risk of bleeding under ECMO

Time frame: Hour 48, Day 7

packed red blood cells transfused

Evaluation of the impact of moderate hypothermia on the risk of bleeding under ECMO

Time frame: Hour 48, Day 7

Infection

Evaluation of the impact of moderate hypothermia on risk of sepsis (pulmonary, blood, venous lines, cannulaes)

Time frame: Hour 48, Day 7, Day 30, Day 60, day 180