This project involves the development, validation and application of a novel test using MRI to assess gastrointestinal motility a vital process that mixes the contents of our digestive tract. This process frequently becomes deranged in conditions like chronic constipation, Parkinson's and Crohn's disease.
Gastrointestinal motility refers to the contractile actions in the gut that serve to mix our food and propel it through out digestive tract. Although known to be involved in a range of conditions like chronic constipation, Parkinson's and Crohn's disease, investigator have never had effective tests with which to study the process. Advances in medical imaging technologies now make it possible to both see and quantify this process non-invasively using MRI. In this study the investigator first of all validate that our MRI based analysis is robust and valid, producing predictable results against range of known stimuli. The investigator then apply the technique to a cohort of participants with Chronic Intestinal Pseudo-Obstruction. These participants are known to have hypo-motile small bowels and demonstration with our MRI technique would serve as further validation. The investigator also investigate two cohorts of people with and without gastrointestinal diseases to better understand how the technique may work in the clinical setting. By the end of this project The investigator will have generated robust initial evidence to validate our MRI technique and clinical data to inform use further research.
Study Type
OBSERVATIONAL
Enrollment
172
Centre for Medical Imaging
London, London, United Kingdom
RECRUITINGTo establish the reproducibility of software quantified small bowel motility in normal individuals using processed MRI derived dynamic small bowel sequences.
Time frame: 7 years
To assess the ability of the software to detect changes in small bowel motility after provocation with a known pro or anti-kinetic agent in normal individuals
Time frame: 7 years
To evaluate the variation in software quantified small bowel motility according to the positioning of the image slice in the abdomen during data acquisition.
Time frame: 7 years
To compare dysmotility patients motility to that of normal controls with and in the absence of pro---kinetic agent.
Time frame: 7 years
To establish basal bowel motility reference ranges in a larger cohort of control, dysmotility and irritable bowel syndrome subjects.
Time frame: 7 years
To assess the reversibility of dysmotility after treatment of the primary underlying condition, if known
Time frame: 7 years
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