The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance of individuals with subjective cognitive decline.
Memory abilities are known to decline during aging, a process that is accelerated in pathological conditions like subjective, mild cognitive impairment (MCI) and Alzheimer's disease (AD), all of which are a growing public-health concern with devastating effects. Polyamines supplementation and corresponding up-regulation of autophagy (i.e., cellular protein degradation pathways) may be a key target of intervention against age-related memory decline. The study will investigate whether a polyamine-enriched dietary supplementation (through capsule intake) could provide positive effects on the cognitive function of elderly individuals (60-80 years old) with subjective cognitive decline.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30
3 months of polyamine supplementation (3 capsules/day)
3 months of placebo intake (3 capsules/day)
Charité Universitätsmedizin Berlin
Berlin, Germany
Change in Cognitive Function (from neuropsychological test battery)
Comparing changes in cognitive function in subjects with polyamine intake and placebo treatment (pre vs. post intervention)
Time frame: Prior to intervention (baseline) and after 3 months of intervention
Laboratory parameters
comparing different markers derived from blood plasma like polyamine concentration (spermine, spermidine) and markers of inflammation pre vs. post intervention
Time frame: Prior to intervention (baseline) and after 3 months of intervention
Vascular parameters
Comparing intima-media-thickness pre vs. post intervention
Time frame: Prior to intervention (baseline) and after 3 months of intervention
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