To optimize the confirmatory tests for primary aldosteronism.
In this study, the investigators aim to optimize the three confirmatory tests: salt loading, captopril challenge and fludrocortisone suppression, and to confirm a better choice of confirming testing for single or combined diagnosis of primary aldosteronism. Additionally, the investigators plan to collect blood and tissue samples of PA patients for genetic testing, and to proceed a long-term follow-up for further investigating the mechanism underlying PA and evaluating the cardio-cerebrovascular complications risk.
Study Type
OBSERVATIONAL
Enrollment
300
The First Affilated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
Area under the receiver operating characteristic curve (AUC) for Salt loading test
Salt loading test will be performed and compared to golden standard such as adrenal venous sampling (AVS) and biopsy results. The area under the curve (AUC) will be calculated.
Time frame: 1 week
AUC for captopril challenge test
Captopril challenge test will be performed and compared to golden standard such as AVS and biopsy results. AUC will be calculated.
Time frame: 1 week
AUC for fludrocortisone suppression test
Fludrocortisone suppression test will be performed and compared to golden standard such as AVS and biopsy results. AUC will be calculated.
Time frame: 1 week
Incidence of cardiovascular diseases in Primary Aldosteronism
Follow-up for the risk of cardiovascular diseases, chronic kidney disease and stroke
Time frame: 3 years
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