Background. Pancreatic cancer surgery is associated with very high risk of postoperative morbidity and mortality. Anastomotic leak (AL) is one of the worst complications associated with relevant short and long-term sequelae. Procalcitonin (PCT) is a biomarker used to monitor bacterial infections and guide antibiotic therapy and has been shown to have better predictive value of AL after colorectal surgery than C-reactive protein (CRP) and white blood cell count (WBC). Purpose. The investigators designed a monocentric pilot study to test if PCT might be a sensitive and reliable marker of AL after pancreatic surgery
Study Type
OBSERVATIONAL
Enrollment
100
measuring CRP and PCT in 3rd and 5th POD after pancreatic cancer resection
Sant'Andrea University Hospital
Rome, Italy
RECRUITINGSensitivity of PCT and CRP for anastomotic leak (AL) after pancreatic surgery
Sensitivity: % of patients corrected identified by the biomarkers having AL; PCT: procalcitonin, CRP: C-reactive protein, AL: anastomic leak
Time frame: 2 yrs
Specificity of PCT and CRP for anastomotic leak (AL) after pancreatic surgery
Specificity: % of pts corrected identified by the biomarkers not having AL; PCT: procalcitonin, CRP: C-reactive protein, AL: anastomic leak
Time frame: 2 yrs
PCT and CRP cuts-off in 3rd POD with a good NPV for AL
PCT: procalcitonin, CRP: C-reactive protein, NPV: negative predictive value
Time frame: 2 yrs
PCT and CRP cuts-off in 5th POD with a good NPV for AL
PCT: procalcitonin, CRP: C-reactive protein, NPV: negative predictive value
Time frame: 2 yrs
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